Disease Overview Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in the bone marrow, leading to bone destruction and marrow failure. The disease is most frequently…
NCCN Clinical Practice Guidelines: Multiple Myeloma
NCCN Clinical Practice Guidelines: Systemic Mastocytosis
Updates to Treatment Protocols Second-Line Therapy for Bone Pain For patients unresponsive to bisphosphonates or those with renal insufficiency contraindicated for bisphosphonates, anti-RANKL monoclonal antibodies (e.g., denosumab) are recommended. FDA-approved…
Chinese Expert Consensus on Antigen Panel Composition for Unexpected Red Blood Cell Antibody Screening and Identification
Recommendations for Antibody Screening Panel Cells Cell Composition Composed of red blood cells (RBCs) from at least three separate O-type donors, confirmed via genetic sequencing to exclude A or B…
Guidelines for Medication Administration: Solvents, Infusion Rates, and Dilution Volumes
1. Compatible Solvents A. Drugs Unsuitable with Sodium Chloride Injection (0.9% NaCl) Cyclophosphamide Cisplatin Amphotericin B Erythromycin Pancuronium Bromide Fleroxacin B. Drugs Unsuitable with Glucose Injection (5% or 10% Dextrose)…
Special Precautions for Medication Use
1. Medications Requiring Increased Water Intake Bronchodilators: Theophylline, aminophylline, diprophylline. Choleretics: Phenylpropanol, hymecromone, dehydrocholic acid, ursodeoxycholic acid. Protease Inhibitors: Ritonavir, indinavir, nelfinavir, amprenavir, lopinavir. Bisphosphonates: Alendronate, pamidronate, clodronate. Antigout Agents:…
Mechanisms and Characteristics of Procoagulant Agents
Procoagulant drugs enhance blood clotting through diverse pathways. Below is a detailed classification of their mechanisms: 1. Coagulation Factor Synthesis Enhancers Vitamin K₁: Essential for hepatic synthesis of coagulation factors…
Three Major Misconceptions About Dysmenorrhea (Menstrual Cramps) and Dietary Management
Dysmenorrhea is a common issue for many women, yet misconceptions about its causes and management persist. Below are three critical misunderstandings and evidence-based approaches to alleviate symptoms: Misconception 1: Self-Medication…
Uterine Factors Contributing to Infertility
The uterus plays a critical role in supporting conception and pregnancy. Successful embryo implantation and fetal development depend on a healthy uterine environment. Below are key uterine factors that can…
Blocked Fallopian Tubes: IVF or Interventional Therapy?
This is a common question in clinical practice, and while there is no one-size-fits-all answer, my professional inclination leans toward in vitro fertilization (IVF). Here’s why: 1. Limitations of Interventional…
Polycystic Ovary Syndrome (PCOS): Causes and Mechanisms
I. Genetic Factors PCOS is associated with autosomal dominant inheritance, X-linked (sex-linked) inheritance, or gene mutations. Most patients exhibit a normal 46,XX karyotype, while others may display chromosomal aberrations or…