Patient Selection Genetic Abnormalities High-risk genetic/molecular lesions (e.g., monosomy 5/del(5q), monosomy 7, high allelic ratio FLT3-ITD mutations): Proceed to hematopoietic stem cell transplantation (HSCT) after achieving first complete remission (CR1). Low-risk…
Disease Overview Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in the bone marrow, leading to bone destruction and marrow failure. The disease is most frequently…
Updates to Treatment Protocols Second-Line Therapy for Bone Pain For patients unresponsive to bisphosphonates or those with renal insufficiency contraindicated for bisphosphonates, anti-RANKL monoclonal antibodies (e.g., denosumab) are recommended. FDA-approved…
Recommendations for Antibody Screening Panel Cells Cell Composition Composed of red blood cells (RBCs) from at least three separate O-type donors, confirmed via genetic sequencing to exclude A or B…
1. Compatible Solvents A. Drugs Unsuitable with Sodium Chloride Injection (0.9% NaCl) Cyclophosphamide Cisplatin Amphotericin B Erythromycin Pancuronium Bromide Fleroxacin B. Drugs Unsuitable with Glucose Injection (5% or 10% Dextrose)…
Procoagulant drugs enhance blood clotting through diverse pathways. Below is a detailed classification of their mechanisms: 1. Coagulation Factor Synthesis Enhancers Vitamin K₁: Essential for hepatic synthesis of coagulation factors…
Dysmenorrhea is a common issue for many women, yet misconceptions about its causes and management persist. Below are three critical misunderstandings and evidence-based approaches to alleviate symptoms: Misconception 1: Self-Medication…
The uterus plays a critical role in supporting conception and pregnancy. Successful embryo implantation and fetal development depend on a healthy uterine environment. Below are key uterine factors that can…
This is a common question in clinical practice, and while there is no one-size-fits-all answer, my professional inclination leans toward in vitro fertilization (IVF). Here’s why: 1. Limitations of Interventional…
I. Genetic Factors PCOS is associated with autosomal dominant inheritance, X-linked (sex-linked) inheritance, or gene mutations. Most patients exhibit a normal 46,XX karyotype, while others may display chromosomal aberrations or…