Low LDL-C Levels Associated with Higher Incidence of Parkinson’s Disease

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Low LDL-C Levels Associated with Higher Incidence of Parkinson’s Disease

Researchers from the University of North Carolina, USA, have reported that individuals with low LDL cholesterol levels have a significantly higher likelihood of developing Parkinson’s disease (PD) compared to those with high LDL-C levels.

Previous studies have shown that PD patients have a lower incidence of heart attacks and strokes compared to non-PD patients. PD patients are also more likely to carry the APOE-2 gene, which is associated with lower LDL-C levels.

Dr. Xuemei Huang and her colleagues investigated whether high LDL cholesterol levels are related to a decreased incidence of Parkinson’s disease, and whether low levels are conversely linked to a higher incidence. The study included 124 PD patients and 112 healthy spouses of patients (controls).

The results indicated that participants with LDL-C levels below 114 mg/dL had a 3.5 times higher incidence of PD than those with LDL-C levels above 138 mg/dL.

Dr. Huang and her team found it interesting that using cholesterol-lowering drugs or statins was associated with a lower incidence of Parkinson’s disease.

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 Vascular Parkinsonism (Arteriosclerotic Pseudoparkinsonism, Vascular Parkinson’s Syndrome) Posted onam9:39 - 05/04/2025

[…] (severe difficulty initiating steps), short shuffling steps, pyramidal signs, and dementia. Unlike Parkinson’s disease (PD), VP lacks resting tremors, shows symmetric rigidity, and responds poorly to levodopa. Key […]

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    david Posted onam5:39 - 05/06/2025

    The symptoms described—severe freezing of gait, bradykinesia, pyramidal signs, and dementia—are characteristic of a condition known as Vascular Parkinsonism (VP). Unlike Parkinson’s disease (PD), VP lacks the hallmark symptom of resting tremor and instead presents with symmetric rigidity. Additionally, VP shows a poor response to levodopa, which is the primary treatment for PD. This distinction is important because it indicates that the pathophysiology of VP differs from PD, often resulting from cerebrovascular events or damage, such as strokes or small vessel disease, rather than the dopaminergic degeneration seen in PD. This lack of response to levodopa also complicates the treatment approach, requiring alternative strategies for symptom management.

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Parkinson's Disease Medication Options – Medical Guidelines Posted onpm9:04 - 05/05/2025

[…] brain. They can be used alone or in conjunction with levodopa, especially in the early stages of Parkinson’s disease. While they may have a lower risk of motor complications, they can cause side effects such as […]

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